#vascular aging

2 articles

Approach: human outcome. Palette: natural.

Close, low-angle shot of an older adult's bare lower leg and bare feet resting on crisp white hospital bed linen, with a soft, out-of-focus window in the background. The camera sits at mattress level and looks along the calf toward the ankle. Face is not visible. A small ultrasound probe coated in clear gel presses against the back of the knee. The operator's gloved hand enters from the frame edge. Soft overcast daylight from the window gives skin tones a warm, realistic look. Around the bed, a sprig of fresh rosemary and a few purple-green ashwagandha leaves sit on a wooden bedside tray. The leaves provide plant-green accents, along with one small electric green sensor light on a monitor. Palette: natural greens, wood browns and warm skin. Mood: quiet, careful and hopeful.

PB125: Biljni Nrf2 spoj koji je održao arterije funkcionalnima tijekom mirovanja u krevetu

BY NOVA CHEN · 31. lis 2026.

Biljni aktivator Nrf2 pod nazivom PB125, sastavljen od ružmarina, ashwagandhe i luteolina, testiran je u malom, dvostruko slijepom ljudskom ispitivanju. Kod 24 starijih osoba, dva tjedna suplementacije od 200 mg/dan podiglo je brahijalni FMD s 2,8 % na 3,8 %, a poplitealni FMD s 1,5 % na 2,3 %. Tijekom pet dana potpune postele, mješavina je sačuvala funkciju arterija i razinu antioksidansa u usporedbi s placebom. Mlađi sudionici nisu pokazali poboljšanje početnog FMD‑a, iako je PB125 štitio poplitealni FMD tijekom imobilizacije udova. S obzirom na mali broj sudionika i posredničke ishode, rezultat predstavlja zanimljiv signal, a ne čvrst dokaz kliničke koristi.

**Approach:** Conceptual metaphor. **Palette:** Bold color field (teal).

A single flexible garden hose, shot from a low three-quarter angle, lies coiled against a saturated teal seamless backdrop. One half of the hose is pale and wrinkled, with a stiff, cracked rubber texture and a visible kink. The other half is supple, glossy and smoothly curved. A thin stream of water arcs from the open end, catching the light. Soft, large-source studio light comes from the upper left and casts gentle, neutral grey shadows with no blue cast. A small electric green brass fitting, with a clean metallic sheen, sits where the two halves meet. The shallow depth of field blurs the coils in the foreground. The mood is quietly doubtful but curious, as if the result is promising and still unproven. There is no text anywhere in the frame.

longevity

Magnezij je omekšao tvrde arterije nakon 6 mjeseci, a zatim je rezultat bio negativan

BY DR. SYNAPSE · 29. lis 2026.

U prvih 12 tjedana magnezij nije pokazao nikakvo mjerljivo poboljšanje krutosti arterija. Tek u 24. tjednu, randomizirano istraživanje na 52 osobe otkrilo je smanjenje brzine pulsnog vala za 1,0 m/s u odnosu na placebo, bez promjene krvnog tlaka. Veća studija iz 2022. s 164 sudionika i tri oblika magnezija nije potvrdila učinak. U članku su prikazani detalji originalne studije, njena ograničenja i kako interpretirati proturječne dokaze.